Description

1-(3,5-Anhydro-2-Deoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of modified nucleosides and nucleotides, which are foundational to antiviral and anticancer therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating enzyme mechanisms, nucleic acid chemistry, and metabolic pathways.
• Pro-drug Development: Serves as a precursor in the design of pro-drugs to enhance bioavailability and targeting.
• Antisense Oligonucleotide Synthesis: A specialized monomer for constructing modified oligonucleotides used in gene therapy and molecular biology applications.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Contract Research: Essential reagent for synthetic organic chemistry projects within universities and CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	1-(3,5-Anhydro-2-Deoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	7481-90-5
Molecular Formula	C10H12N2O5
Molecular Weight	240.21 g/mol
Synonyms	5-Methyl-2'-deoxyuridine 2',3'-anhydro derivative; 1-(2,3-Anhydro-5-O-trityl-β-D-lyxofuranosyl)thymine (related intermediate); Thymine anhydro nucleoside; 2',3'-Anhydro-5-methyl-2'-deoxyuridine; 1-(3,5-Anhydro-2-deoxy-β-D-threo-pentofuranosyl)-5-methyluracil; Anhydrothymidine; 5-Methyldeoxyuridine 2',3'-anhydronucleoside
EINECS	Contact for details

Quality Control

Our 1-(3,5-Anhydro-2-Deoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.