Description

1-Methylpiperidine-4-Carbonyl Chloride Hydrochloride is a versatile and reactive chemical building block, primarily used as a key intermediate in sophisticated organic synthesis. Its value lies in its ability to introduce the 1-methylpiperidine-4-carbonyl moiety, a crucial structural motif in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the piperidine scaffold is a common feature.
• Chemical Research & Development: Serves as a versatile reagent in academic and industrial R&D labs for constructing complex heterocyclic compounds and exploring new chemical spaces.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organocatalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced functional materials.

Basic Information

Product Name	1-Methylpiperidine-4-Carbonyl Chloride Hydrochloride
CAS No.	7462-84-2
Molecular Formula	C8H15Cl2NO
Molecular Weight	212.12 g/mol
Synonyms	1-Methyl-4-piperidinecarbonyl chloride hydrochloride; 4-(Chloroformyl)-1-methylpiperidine hydrochloride; N-Methylisonipecotoyl chloride hydrochloride; 1-Methylpiperidine-4-carboxylic acid chloride hydrochloride; Isonipecotoyl chloride, 1-methyl-, hydrochloride; 4-Carbamoyl-1-methylpiperidinium chloride
EINECS	Contact for details

Quality Control

Our 1-Methylpiperidine-4-Carbonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.