Description

N-Methyl-N-(Trimethylsilyl)Acetamide is a versatile organosilicon reagent primarily used as a silylating agent and a protecting group in organic synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) group, which can modify reactivity, enhance volatility for analysis, or protect sensitive functional groups. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthetic routes.

Application

• Silylating Agent in Organic Synthesis: Used to protect hydroxyl (-OH) and amine (-NH) groups, facilitating multi-step reactions in complex molecule construction.
• Derivatization for Gas Chromatography (GC): Enhances the volatility and thermal stability of polar compounds like carbohydrates, steroids, and organic acids for improved GC-MS analysis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and other bioactive molecules.
• Reagent for Peptide Synthesis: Can be employed in the modification or protection of amino acids during peptide coupling procedures.
• Production of Silicon-Containing Polymers: Acts as a monomer or modifying agent in the synthesis of specialized silicones and hybrid organic-inorganic materials.
• Laboratory Research & Development: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies.

Basic Information

Product Name	N-Methyl-N-(Trimethylsilyl)Acetamide
CAS No.	7449-74-3
Molecular Formula	C6H15NOSi
Molecular Weight	145.28 g/mol
Synonyms	N-Methyl-N-(trimethylsilyl)acetamide; Acetamide, N-methyl-N-(trimethylsilyl)-; N-Methyl-N-trimethylsilylacetamide; MSA; N-Methylacetamide, N-trimethylsilyl-; N-(Trimethylsilyl)-N-methylacetamide; TMS-MSA
EINECS	Contact for details

Quality Control

Our N-Methyl-N-(Trimethylsilyl)Acetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed and may require handling under an inert atmosphere for long-term storage or after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.