Description

2',3',5'-Tri-o-Acetyl-D-Adenosine is a key protected nucleoside derivative, specifically the triacetylated form of D-adenosine. This compound is a vital high-purity building block in the synthesis of modified oligonucleotides, nucleoside analogs, and pharmaceutical intermediates. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and fine chemical synthesis who require precise molecular scaffolds for drug discovery and advanced biochemical applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutics.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and signaling pathways.
• Prodrug Development: The acetyl groups can be utilized in prodrug strategies to enhance the bioavailability of adenosine-derived active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Fine Chemical Synthesis: A versatile chiral starting material for the preparation of more complex, stereochemically defined molecules in medicinal chemistry.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-D-Adenosine
CAS No.	7387-57-7
Molecular Formula	C16H19N5O7
Molecular Weight	393.35 g/mol
Synonyms	D-Adenosine, 2',3',5'-triacetate; 9-β-D-Ribofuranosyladenine 2',3',5'-triacetate; 2',3',5'-Tri-O-acetyladenosine; N6-Amino-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; Triacetyladenosine; D-Triacetyladenosine; Adenosine 2',3',5'-triacetate
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-D-Adenosine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) documenting all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.