Description

1,3-Cyclobutanedicarbonyl Chloride, trans- (8Ci) is a high-purity, reactive diacid chloride derivative of cyclobutane. This compound serves as a critical bifunctional building block for the synthesis of complex organic molecules, particularly in the development of novel polymers and active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-quality intermediates for ring-opening polymerizations and the construction of strained ring systems.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those containing cyclobutane rings for enhanced biological activity.
• Polymer Chemistry: Monomer for the production of specialty polyamides, polyesters, and polyimides with unique thermal and mechanical properties.
• Agrochemical Synthesis: Building block for creating advanced herbicides and fungicides with specific stereochemistry.
• Ligand and Catalyst Development: Used to synthesize chelating ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in developing high-performance engineering plastics and resins.
• Cross-linking Agent: Functions as a reactive cross-linker in coatings and adhesives formulations to improve durability.

Basic Information

Product Name	1,3-Cyclobutanedicarbonyl Chloride, trans- (8Ci)
CAS No.	7371-72-4
Molecular Formula	C6H6Cl2O2
Molecular Weight	181.02 g/mol
Synonyms	trans-1,3-Cyclobutanedicarbonyl Dichloride; trans-Cyclobutane-1,3-dicarbonyl Dichloride; (1r,3r)-Cyclobutane-1,3-dicarbonyl Dichloride; (1s,3s)-Cyclobutane-1,3-dicarbonyl Dichloride; 1,3-Cyclobutanedicarboxylic Acid Dichloride, trans-; NSC 163083
EINECS	Contact for details

Quality Control

Our 1,3-Cyclobutanedicarbonyl Chloride, trans- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.