Description

(S)-3-Hydroxy-γ-Butyrolactone CAS NO 7331-52-4 is a high-value chiral building block and intermediate of significant importance in asymmetric synthesis. This optically active lactone is prized for its versatility in constructing complex molecular architectures with defined stereochemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the development of active pharmaceutical ingredients (APIs), natural product analogs, and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various drug candidates, including statins (cholesterol-lowering agents) and other bioactive molecules.
• Asymmetric Synthesis: Used as a starting material or precursor in stereoselective reactions to introduce the (S)-3-hydroxybutanoate moiety into target compounds.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products that contain the 3-hydroxy-γ-butyrolactone structural motif.
• Agrochemical Research: Serves as an intermediate in the development of chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.

Basic Information

Product Name	(S)-3-Hydroxy-γ-Butyrolactone
CAS No.	7331-52-4
Molecular Formula	C4H6O3
Molecular Weight	102.09 g/mol
Synonyms	(S)-3-Hydroxybutyrolactone; (S)-3-Hydroxydihydro-2(3H)-furanone; (S)-3-Hydroxy-γ-butyrolactone; (S)-Tetrahydro-3-hydroxy-2-furanone; (3S)-3-Hydroxydihydrofuran-2(3H)-one; (S)-(-)-3-Hydroxy-γ-butyrolactone; L-3-Hydroxy-γ-butyrolactone
EINECS	Contact for details

Quality Control

Our (S)-3-Hydroxy-γ-Butyrolactone is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR, and purity assessment. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-40° to -44° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.