Description

5-(Hydroxymethyl)-2'-Deoxycytidine is a modified nucleoside of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial building block and intermediate in the synthesis of oligonucleotides and nucleotide analogs. It is primarily utilized by research institutions and manufacturers in the fields of nucleic acid chemistry, antiviral drug development, and epigenetics research. Its unique hydroxymethyl modification makes it a valuable precursor for exploring DNA modifications and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Oligonucleotide Synthesis: Used as a modified building block for constructing DNA strands with specific functional groups for research and diagnostic applications.
• Biochemical Research: Essential tool in epigenetics studies, particularly for investigating hydroxymethylcytosine and its role in gene regulation.
• Pro-drug Development: Serves as a starting material for creating nucleoside pro-drugs with enhanced cellular uptake and metabolic stability.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic Research: Fundamental reagent in university and institutional labs for studying DNA repair mechanisms and nucleic acid biochemistry.

Basic Information

Product Name	5-(Hydroxymethyl)-2'-Deoxycytidine
CAS No.	7226-77-9
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	5-Hydroxymethyl-2'-deoxycytidine; 5-Hydroxymethyldeoxycytidine; hm5dC; 5hmdC; 5-(Hydroxymethyl)deoxycytidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione; 5-Hydroxymethylcytosine deoxyriboside
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl)-2'-Deoxycytidine is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.