Description

Trimethaphan is a potent ganglionic blocking agent and a non-depolarizing neuromuscular agent, primarily recognized for its rapid-acting hypotensive effects. This compound is of significant interest in pharmacological research and development, particularly for studying autonomic nervous system control and acute blood pressure management. It serves as a critical reference standard and active pharmaceutical ingredient (API) for researchers and manufacturers in the pharmaceutical and life sciences sectors. Trimethaphan CAS NO 7187-66-8 is supplied under stringent quality controls to ensure reliability for sensitive applications.

Application

• Pharmaceutical Research & Development: As a key reference standard for analytical method development, validation, and quality control of related drug products.
• Active Pharmaceutical Ingredient (API): Used in the formulation and manufacturing of specialized parenteral medications for controlled hypotension.
• Pharmacological Studies: A vital tool in preclinical and clinical research for investigating ganglionic blockade, autonomic physiology, and cardiovascular drug mechanisms.
• Academic & Institutional Research: Employed in university and institutional labs for teaching and advanced studies in neuropharmacology and anesthesiology.
• Biochemical Assays: Utilized as a specific agent in in vitro assays to study receptor interactions and signal transduction pathways.

Basic Information

Product Name	Trimethaphan
CAS No.	7187-66-8
Molecular Formula	C22H25N2O5S3+
Molecular Weight	497.64 g/mol
Synonyms	Trimethaphan Camsylate; Trimethaphan Camphorsulfonate; Arfonad; Methioplegium; Ro 2-2222; 4,6,7,8,9,10-Hexahydro-9,10-[(1-methylethylidene)bis(oxy)]-2-methyl-5H-pyrimido[4,5-d]thieno[3,2-f][1,4]thiazepin-5-ium camphorsulfonate; Ganglioplegin
EINECS	Contact for details

Quality Control

Our Trimethaphan is manufactured and tested under a strict quality management system to ensure batch-to-batch consistency and compliance with relevant standards for research and pharmaceutical use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques such as HPLC, NMR, and mass spectrometry. We support compliance with cGMP guidelines where applicable, and specifications can be aligned with USP/EP monograph requirements for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.