Description

Cholesteryl Chloroformate is a versatile cholesterol-derived reagent, primarily used as a key intermediate in organic synthesis and pharmaceutical research. Its value lies in its ability to introduce the cholesteryl moiety or act as a protecting group for amines, facilitating the creation of novel compounds with specific biological or material properties. This product is essential for researchers and manufacturers in the pharmaceutical, life sciences, and advanced materials sectors, particularly those developing drug delivery systems, liquid crystals, or specialized polymers.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of prodrugs and targeted therapeutic agents, leveraging cholesterol's role in cellular uptake.
• Lipid Conjugation & Derivatization: Used to modify peptides, proteins, or other bioactive molecules to enhance their lipophilicity, stability, or membrane permeability.
• Polymer & Material Science: Serves as a monomer or modifying agent for creating functional polymers, liquid crystalline materials, and cholesterol-based gels.
• Chromatography & Analytical Standards: Employed in the preparation of reference standards and derivatives for analytical methods like HPLC or mass spectrometry.
• Bioconjugation & Probe Synthesis: Facilitates the labeling of biomolecules with cholesterol tags for imaging, tracking, or diagnostic applications.
• Research & Development: A fundamental tool in academic and industrial R&D for exploring new chemical entities and their biological interactions.

Basic Information

Product Name	Cholesteryl Chloroformate
CAS No.	7144-08-3
Molecular Formula	C28H45ClO2
Molecular Weight	449.11 g/mol
Synonyms	Cholesteryl Chloroformate; Cholesterol Chloroformate; 3β-Cholest-5-en-3-yl Chloroformate; Cholest-5-en-3β-yl Chloroformate; Chloroformic Acid Cholesteryl Ester; 5-Cholesten-3β-yl Chloroformate; NSC 35753
EINECS	230-447-6

Quality Control

Our Cholesteryl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including purity by HPLC, identity confirmation by IR and NMR, and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality system is designed to support research and production needs in compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	~115-120 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.