Description

(2S)-2-Amino-3-[4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]Propanoic Acid is a highly specialized iodinated aromatic amino acid derivative, serving as a critical building block in advanced pharmaceutical research and development. Its unique molecular structure, featuring multiple iodine atoms on a phenolic ring system, makes it a valuable precursor for synthesizing thyroid hormone analogs, receptor ligands, and diagnostic imaging agents. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focusing on endocrinology, radiopharmaceuticals, and targeted therapeutics.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel thyroid hormone receptor (TR) agonists and antagonists.
• Radiopharmaceutical Research: Serves as a non-radioactive scaffold for designing iodine-123 or iodine-131 labeled compounds for SPECT imaging and therapy.
• Biochemical Probe Development: Used in creating labeled probes for studying thyroid hormone transport, metabolism, and receptor binding assays.
• Organic Synthesis Building Block: Employed in complex organic syntheses requiring regioselectively iodinated phenolic and amino acid motifs.
• Reference Standard: Acts as a high-purity analytical standard for quality control in the production of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2S)-2-Amino-3-[4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]Propanoic Acid
CAS No.	7013-53-8
Molecular Formula	C15H12I3NO4
Molecular Weight	706.88 g/mol
Synonyms	L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; 3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-L-alanine; 3,3',5-Triiodothyroacetic Acid precursor; TRIAC precursor; T3 Analog Intermediate; 7013-53-8; (S)-2-Amino-3-(4-((4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-Amino-3-[4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]Propanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, chiral purity, and related substances. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.