Description

6-Thio-2'-Deoxyguanosine is a chemically modified nucleoside analog where the oxygen atom at the 6-position of the guanine base is replaced by a sulfur atom. This modification is of significant interest in biochemical and pharmaceutical research due to its ability to interfere with telomerase activity and DNA replication. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, molecular biology, and the development of novel therapeutic agents.

Application

• Oncology Research: Investigated as a potential telomerase inhibitor for cancer therapy studies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases and telomerase.
• Antiviral Research: Explored for its potential activity against viral replication mechanisms.
• Molecular Probes: Serves as a building block for synthesizing labeled nucleotides or probes for diagnostic assays.
• Pharmaceutical Development: A key intermediate in the research and development of novel nucleoside-based drugs.
• Academic Studies: Used in university laboratories for teaching and advanced research in nucleic acid chemistry and cell biology.

Basic Information

Product Name	6-Thio-2'-Deoxyguanosine
CAS No.	789-61-7
Molecular Formula	C10H13N5O3S
Molecular Weight	283.31 g/mol
Synonyms	6-Thio-dG; 6-Thio-2'-deoxyguanosine; 2'-Deoxy-6-thioguanosine; 6-SH-dG; 6-Thio-deoxyguanosine; 6-Thioguanine deoxyriboside; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-sulfanyl-1H-purin-2-one
EINECS	Contact for details

Quality Control

Our 6-Thio-2'-Deoxyguanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.