Description

3,5-Bis(Trifluoromethyl)Benzoyl Chloride is a highly reactive and versatile aromatic acid chloride derivative, distinguished by the presence of two powerful electron-withdrawing trifluoromethyl groups. This structural motif makes it an indispensable key building block in advanced organic synthesis, particularly for introducing the lipophilic and metabolically stable 3,5-bis(trifluoromethyl)benzoyl moiety. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule drugs where the bis-CF₃ group enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where its derivative compounds offer improved environmental stability and efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated ligands used in asymmetric catalysis and organometallic chemistry.
• Functional Material Precursor: Employed in the synthesis of monomers and polymers for specialty plastics, coatings, and electronic materials that require specific fluorinated properties.
• Custom Synthesis & Contract Manufacturing: A high-value reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Research & Development: A staple in medicinal chemistry and process chemistry labs for scaffold diversification and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzoyl Chloride
CAS No.	785-56-8
Molecular Formula	C₉H₃ClF₆O
Molecular Weight	276.56 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzoyl chloride; α,α,α,α',α',α'-Hexafluoro-3,5-dimethylbenzoyl chloride; Benzoyl chloride, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzoyl chloride; 3,5-Bis(trifluoromethyl)benzoic acid chloride; 785-56-8; 3,5-Bis(trifluoromethyl)benzoylchloride
EINECS	212-326-8

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.