Description

2'-Fluoro-2'-Deoxyuridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and biochemical research. This compound is valued for its role as a precursor in the synthesis of antiviral and anticancer agents, particularly those targeting viral DNA polymerases and cellular replication pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of antiviral drugs (e.g., nucleoside reverse transcriptase inhibitors) and chemotherapeutic agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA synthesis mechanisms and polymerase activity.
• Antiviral Agent Development: Serves as a core scaffold for developing novel compounds active against herpesviruses, hepatitis viruses, and other DNA viruses.
• Radiopharmaceuticals: Potential use as a precursor for fluorinated probes in Positron Emission Tomography (PET) imaging.
• Molecular Biology: Utilized in studies of cell proliferation, apoptosis, and the mechanism of action of fluoropyrimidines.
• Academic & Contract Research: A standard reagent for universities and CROs conducting research in oncology, virology, and nucleotide metabolism.

Basic Information

Product Name	2'-Fluoro-2'-Deoxyuridine
CAS No.	784-71-4
Molecular Formula	C9H11FN2O5
Molecular Weight	246.19 g/mol
Synonyms	2'-F-2'-dU; 2'-Fluoro-2'-deoxyuridine; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5-Fluoro-2'-deoxyuridine (Note: This is a positional isomer, often searched in relation); FdU; 2'-Fluoro-2'-deoxy-uridine; 2'-F-dUrd; NSC 27640
EINECS	212-326-6

Quality Control

Our 2'-Fluoro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with research and cGMP-grade standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.