Description

4-Nitrophenyl Phosphorodichloridate is a key organophosphorus reagent widely used in chemical synthesis. Its primary value lies in its role as a versatile phosphorylating and coupling agent, enabling the formation of phosphate esters and nucleotides. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science industries, particularly in oligonucleotide synthesis and the development of prodrugs.

Application

• Phosphorylation Reagent in the synthesis of nucleotides, nucleoside phosphates, and their analogs.
• Key Intermediate for oligonucleotide and phosphorothioate synthesis, critical for antisense and siRNA therapeutics.
• Prodrug Synthesis, particularly for creating phosphate ester prodrugs to enhance drug bioavailability.
• Agrochemical Intermediate in the manufacture of certain insecticides and herbicides.
• Bioconjugation Chemistry for labeling biomolecules with phosphate groups.
• Polymer Chemistry as a monomer or cross-linking agent for specialty polymers.
• Research & Development in medicinal chemistry and biochemistry for probing enzyme mechanisms.

Basic Information

Product Name	4-Nitrophenyl Phosphorodichloridate
CAS No.	777-52-6
Molecular Formula	C6H4Cl2NO4P
Molecular Weight	255.98 g/mol
Synonyms	Phosphorodichloridic Acid, 4-Nitrophenyl Ester; p-Nitrophenyl Phosphorodichloridate; Phosphorodichloridous Acid 4-Nitrophenyl Ester; 4-Nitrophenyl Dichlorophosphate; Dichloro(4-nitrophenoxy)phosphine Oxide; NSC 404062
EINECS	212-289-5

Quality Control

Our 4-Nitrophenyl Phosphorodichloridate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.