Description

Benzenepropanoyl Chloride, 4-Fluoro- is a versatile fluorinated aromatic acid chloride intermediate. This compound is critical for introducing the 4-fluorophenylpropionyl moiety into target molecules, enabling precise structural modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including potential CNS agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and charge-transport materials in electronic displays.
• Peptide & Protein Modification: Employed as an acylating agent to modify amino groups, useful in bioconjugation and probe development.
• Polymer Chemistry: Acts as a monomer or chain modifier in the synthesis of specialty polyamides and polyesters with unique properties.
• Chemical Research: Fundamental reagent in organic synthesis for Friedel-Crafts acylation and nucleophilic acyl substitution reactions to create complex fluorinated structures.

Basic Information

Product Name	Benzenepropanoyl Chloride, 4-Fluoro-
CAS No.	772-70-3
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	4-Fluorophenylpropionyl Chloride; 4-Fluorohydrocinnamoyl Chloride; 3-(4-Fluorophenyl)propanoyl Chloride; 4-Fluoro-β-phenylpropionyl Chloride; 3-(p-Fluorophenyl)propionyl Chloride; 4-Fluorobenzene propanoyl chloride; 4-Fluorohydrocinnamic acid chloride; 4-Fluoro-3-phenylpropionyl chloride
EINECS	212-247-9

Quality Control

Our Benzenepropanoyl Chloride, 4-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and strong bases; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.