Description

Trimethoprim CAS NO 738-70-5 is a synthetic antibacterial agent belonging to the diaminopyrimidine class. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) valued for its potent inhibition of bacterial dihydrofolate reductase. This compound is essential for manufacturers in the pharmaceutical and veterinary medicine sectors, where it is used in the formulation of antibacterial combination therapies.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in human antibacterial medications, often in combination with sulfonamides (e.g., co-trimoxazole).
• Key component in veterinary pharmaceuticals for the treatment of bacterial infections in livestock and companion animals.
• Intermediate in the synthesis of more complex antimicrobial agents and pharmaceutical compounds.
• Used in research and development for studying bacterial resistance mechanisms and developing new therapeutic agents.
• Reference standard in analytical laboratories for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Trimethoprim
CAS No.	738-70-5
Molecular Formula	C14H18N4O3
Molecular Weight	290.32 g/mol
Synonyms	2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine; Trimpex; Proloprim; Ipral; Synaprim; TMP; BW 56-72
EINECS	212-006-2

Quality Control

Our Trimethoprim is manufactured under strict quality management systems. It is produced to meet high-purity standards suitable for pharmaceutical applications, with testing protocols aligned with major pharmacopoeias. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Complies with pharmacopoeial limits
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.