Description

Pentoxyverine is a synthetic, non-narcotic antitussive agent belonging to the chemical class of piperidine derivatives. It is valued for its selective action on the cough center in the medulla oblongata, providing effective cough suppression with a favorable safety profile. This active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry formulating cough suppressant medications, including syrups, tablets, and lozenges.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter (OTC) antitussive (cough suppressant) formulations.
• Cough Syrup Production: A key component in liquid oral dosage forms designed for symptomatic relief of non-productive cough.
• Solid Dosage Forms: Used in the manufacture of coated or uncoated tablets and lozenges for convenient cough management.
• Pediatric Formulations: Incorporated into specially calibrated pediatric cough medicines due to its established efficacy and dosage flexibility.
• Combination Therapies: May be formulated in combination with other APIs, such as expectorants or antihistamines, in multi-symptom cold and cough remedies.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for managing cough in animals.

Basic Information

Product Name	Pentoxyverine
CAS No.	77-23-6
Molecular Formula	C20H31NO3
Molecular Weight	333.47 g/mol
Synonyms	Carbetapentane; 2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate; Toclase; Sedotussin; Atussil; Pectrol; Pentoxyverine Citrate (salt form); Pirexyl
EINECS	201-011-5

Quality Control

Our Pentoxyverine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee supply chain transparency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.