Description

Dovitinib Lactate CAS NO 692737-80-7 is the lactate salt form of Dovitinib, a potent and selective multi-targeted receptor tyrosine kinase (RTK) inhibitor. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly in oncology. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in the discovery and development of novel cancer therapeutics targeting key signaling pathways.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control (QC) of drug substances and products.
• Biochemical Research: Used as a potent inhibitor in in vitro studies to investigate the role of specific tyrosine kinases (e.g., FLT3, VEGFR, FGFR) in cellular signaling and tumorigenesis.
• Preclinical Drug Development: Employed as a key intermediate in the synthesis and formulation studies for developing Dovitinib-based anticancer agents.
• Mechanism of Action (MoA) Studies: Essential for studying drug-target interactions, pharmacokinetics, and pharmacodynamics in research models.
• High-Throughput Screening (HTS): Used as a control compound in screening assays to identify new drug candidates or to validate assay systems.

Basic Information

Product Name	Dovitinib Lactate
CAS No.	692737-80-7
Molecular Formula	C₂₁H₂₁FN₆O • C₃H₆O₃
Molecular Weight	506.52 g/mol
Synonyms	TKI258 Lactate; CHIR-258 Lactate; (3Z,5Z)-3-[(2,4-Dimethyl-1H-pyrrol-5-yl)methylene]-5-(1H-pyrrol-2-ylmethylene)-1-methylpiperidine-2,4-dione Lactate; Dovitinib (Lactate); Dovitinib Dilactate; TK1258 Lactate
EINECS	Contact for details

Quality Control

Our Dovitinib Lactate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.