Description

Poloxamer 188 is a non-ionic, amphiphilic block copolymer surfactant widely recognized for its excellent biocompatibility and solubilizing properties. This versatile excipient is crucial for enhancing the stability, solubility, and bioavailability of active pharmaceutical ingredients. It is an essential material for formulators and manufacturers in the pharmaceutical, biotechnology, and personal care industries seeking reliable and high-purity functional ingredients.

Application

• Pharmaceutical Formulations: Used as a solubilizer, emulsifier, and stabilizer in injectable, oral, and topical drug products.
• Biotechnology: Acts as a cell membrane protectant (cryoprotectant) in cell culture and bioprocessing applications.
• Medical Devices: Employed as a coating agent to reduce protein adsorption and improve biocompatibility of implants and diagnostic devices.
• Personal Care & Cosmetics: Functions as an emulsifier and solubilizer in creams, lotions, and other topical preparations.
• Industrial Applications: Serves as a dispersant, wetting agent, and stabilizer in various chemical processes and material sciences.

Basic Information

Product Name	Poloxamer 188
CAS No.	691397-13-4
Molecular Formula	(C2H4O)a(C3H6O)b(C2H4O)a
Molecular Weight	~8400-9500 g/mol (typical)
Synonyms	Poloxamer 188; Pluronic F68; Lutrol F68; Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Oxirane, methyl-, polymer with oxirane, block; Polyoxyethylene-polyoxypropylene block copolymer; Poloxalkol; Nonionic surfactant F68
EINECS	Contact for details

Quality Control

Our Poloxamer 188 is manufactured under strict quality management systems. It can be supplied to meet various pharmacopeial standards, including USP-NF and Ph. Eur. monographs. All batches undergo rigorous analytical testing to ensure identity, purity, and performance. A comprehensive Certificate of Analysis (COA) detailing specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); protect from excessive humidity and absorb moisture promptly after opening.

Specification

Item	Specification
Appearance	White to off-white waxy solid or flakes
Identification (IR)	Conforms
Assay (Oxyethylene Content)	79.9% - 83.7%
Average Molecular Weight	7680 - 9510
pH (1% Solution)	5.0 - 7.5
Loss on Drying	≤ 1.0 %
Residue on Ignition	≤ 0.4 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.