Description

n-Formyl-D-Ribofuranosyl-3-Guanylurea (α/β-Mixture) is a specialized nucleoside derivative, a key building block in advanced organic synthesis and pharmaceutical research. This compound matters for its role as a crucial intermediate in the development of novel antiviral agents and modified oligonucleotides, where precise molecular structure is paramount. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of nucleoside analogs, antiviral drug discovery, and the development of RNA-targeting therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a modified ribonucleoside building block for constructing specialized RNA sequences in research and therapeutic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and RNA processing.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting viral polymerases.
• Reference Standard: Utilized as an analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	n-Formyl-D-Ribofuranosyl-3-Guanylurea (α/β-Mixture)
CAS No.	686299-20-7
Molecular Formula	C12H16N4O8
Molecular Weight	344.28 g/mol
Synonyms	3-[(Formylamino)methylideneamino]-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea; 1-(β-D-Ribofuranosyl)-3-(N-formylamidino)urea; N-Formyl-3-guanylurea ribonucleoside; 3-Guanylurea, N-formyl-, D-ribofuranosyl derivative; α/β-n-Formyl-3-guanylurea riboside; FRGU; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-Formyl-D-Ribofuranosyl-3-Guanylurea (α/β-Mixture) is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
α/β Anomer Ratio (HPLC)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.