Description

1H-1,2,4-Triazol-3-Amine, 1-Pentofuranosyl- (9Ci) is a specialized nucleoside analog building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key synthetic intermediate for novel antiviral and anticancer agents, particularly those targeting nucleic acid synthesis. This high-purity compound is essential for research chemists and process development scientists in the pharmaceutical and biotechnology industries. Its precise structure enables the exploration of new therapeutic mechanisms and the development of next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Research: Used in the R&D of compounds targeting viral polymerases and reverse transcriptases for diseases such as hepatitis and HIV.
• Oncology Drug Discovery: Serves as a precursor in the development of chemotherapeutic agents that interfere with DNA/RNA replication in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of complex active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the contract synthesis of more complex, proprietary molecules for clinical trials.

Basic Information

Product Name	1H-1,2,4-Triazol-3-Amine, 1-Pentofuranosyl- (9Ci)
CAS No.	686299-18-3
Molecular Formula	C7H10N4O4
Molecular Weight	214.18 g/mol
Synonyms	1-(β-D-Ribofuranosyl)-1H-1,2,4-triazol-3-amine; 3-Amino-1-β-D-ribofuranosyl-1,2,4-triazole; 1-(β-D-Ribofuranosyl)-1H-1,2,4-triazol-3-ylamine; Ribofuranosyltriazolylamine; 1-(β-D-Ribofuranosyl)-1H-1,2,4-triazole-3-amine; 3-Amino-1-(β-D-ribofuranosyl)-1,2,4-triazole; Nucleoside triazole amine derivative
EINECS	Contact for details

Quality Control

Our production of 1H-1,2,4-Triazol-3-Amine, 1-Pentofuranosyl- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.