Description

4-Thiazolecarbonyl Chloride, 5-(Difluoromethyl)-2-Methyl- (9Ci) is a high-value, reactive organofluorine building block. This compound is critical for the synthesis of advanced heterocyclic molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex thiazole-based scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, antibacterial, and anticancer research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for functionalized thiazole monomers in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO companies offering bespoke synthesis services.
• Academic & Industrial R&D: Fundamental research reagent for exploring new reactions and methodologies in organofluorine and heterocyclic chemistry.

Basic Information

Product Name	4-Thiazolecarbonyl Chloride, 5-(Difluoromethyl)-2-Methyl- (9Ci)
CAS No.	685565-98-4
Molecular Formula	C6H4ClF2NOS
Molecular Weight	195.61 g/mol
Synonyms	5-(Difluoromethyl)-2-methyl-1,3-thiazole-4-carbonyl chloride; 5-(Difluoromethyl)-2-methylthiazole-4-carbonyl chloride; 2-Methyl-5-(difluoromethyl)-4-thiazolecarbonyl chloride; 4-Carbonyl chloride-5-(difluoromethyl)-2-methylthiazole; 685565-98-4; 5-Difluoromethyl-2-methyl-thiazole-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Thiazolecarbonyl Chloride, 5-(Difluoromethyl)-2-Methyl- (9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the exacting standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.