Description

Tivozanib (Hydrate) is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. This compound is of significant interest for its targeted anti-angiogenic activity, which is a critical mechanism in oncology research and development. It serves as a key active pharmaceutical ingredient (API) and reference standard for pharmaceutical manufacturers and research institutions focused on developing novel cancer therapeutics, particularly for renal cell carcinoma and other solid tumors.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of investigational and commercial oncology drugs.
• Critical reference standard for quality control, analytical method development, and validation in pharmaceutical R&D and manufacturing.
• Preclinical and clinical research into VEGFR-targeted therapies for various cancers, including renal cell carcinoma.
• Biochemical research tool for studying angiogenesis inhibition and tyrosine kinase signaling pathways.
• Development of combination therapies with other anticancer agents to enhance efficacy.

Basic Information

Product Name	Tivozanib (Hydrate)
CAS No.	682745-40-0
Molecular Formula	C22H19ClN4O5 • xH2O
Molecular Weight	454.86 g/mol (Anhydrous basis)
Synonyms	Tivozanib Monohydrate; AV-951; KRN-951; 1-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-3-(5-methyl-1,2,4-oxadiazol-3-yl)urea hydrate; Tivozanib Hydrate; Fotivda (Trade Name); VEGFR Inhibitor AV-951
EINECS	Contact for details

Quality Control

Our Tivozanib (Hydrate) is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring suitability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	3.0% - 6.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.