Description

Bucladesine CAS NO 681435-26-7 is a cell-permeable, phosphodiesterase-resistant analog of cyclic adenosine monophosphate (cAMP). This compound is a crucial research tool for studying intracellular signaling pathways, particularly those mediated by cAMP-dependent protein kinase (PKA). It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, cell biology studies, and biochemical research.

Application

• Biochemical Research: Acts as a stable cAMP analog to activate PKA and study downstream signaling cascades in cell-based assays.
• Drug Discovery & Development: Used as a reference standard or pharmacological tool compound in high-throughput screening and target validation.
• Cell Biology Studies: Investigates the role of cAMP in cellular processes such as metabolism, gene expression, and cell differentiation.
• Neuroscience Research: Explores cAMP/PKA pathways in neuronal function, synaptic plasticity, and neuroprotection.
• Cardiovascular Research: Studies the effects of cAMP signaling on heart muscle contraction and vascular tone.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	Bucladesine
CAS No.	681435-26-7
Molecular Formula	C18H24N5O8P
Molecular Weight	469.39 g/mol
Synonyms	N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate; Dibutyryl cAMP; dbcAMP; Dibutyryl cyclic AMP; Bucladesine sodium; DBcAMP; N6,O2'-Dibutyryladenosine-3',5'-cyclic monophosphate
EINECS	Contact for details

Quality Control

Our Bucladesine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.