Description

(3,3-Difluorocyclobutyl)Methanol is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique cyclobutane core, functionalized with both fluorine atoms and a hydroxymethyl group, makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclobutyl moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty monomers to modify material properties like chemical resistance and surface energy.
• Fluorine Chemistry Exploration: A valuable substrate for studying novel fluorination reactions and the effects of the gem-difluorocyclobutane group on molecular conformation and reactivity.

Basic Information

Product Name	(3,3-Difluorocyclobutyl)Methanol
CAS No.	681128-39-2
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	3,3-Difluorocyclobutanemethanol; (3,3-Difluorocyclobutyl)methanol; 1-(Hydroxymethyl)-3,3-difluorocyclobutane; 3,3-Difluorocyclobutane-1-methanol; 681128-39-2; (3,3-Difluorocyclobutyl)methanol; 3,3-Difluorocyclobutylmethanol
EINECS	Contact for details

Quality Control

Our (3,3-Difluorocyclobutyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.