Description

Aicar (Phosphate) CAS NO 681006-28-0 is the phosphorylated, active form of the nucleoside analog 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), a key intermediate in purine biosynthesis. This compound is a potent activator of AMP-activated protein kinase (AMPK), making it a critical research tool for studying cellular energy homeostasis, metabolic pathways, and signal transduction. It is essential for researchers and developers in the fields of pharmaceutical development, metabolic disease research, and biochemical screening.

Application

• Biochemical Research: As a standard and positive control in studies investigating AMPK signaling pathways, glucose uptake, and fatty acid oxidation.
• Pharmaceutical R&D: A key reference compound for developing novel therapeutics targeting metabolic disorders such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).
• Cell Biology Studies: Used to induce metabolic stress and study cellular responses, autophagy, and mitochondrial function in various cell lines.
• Sports Science Research: Investigated for its effects on exercise performance, endurance, and muscle metabolism in preclinical models.
• High-Throughput Screening (HTS): Employed as a pharmacological tool in assay development and compound library screening for AMPK-related targets.
• Academic Research: Fundamental studies in biochemistry and molecular biology to elucidate metabolic regulation and energy-sensing mechanisms.

Basic Information

Product Name	Aicar (Phosphate)
CAS No.	681006-28-0
Molecular Formula	C9H15N4O9P
Molecular Weight	354.21 g/mol
Synonyms	5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate; AICAR Monophosphate; AICAR-P; Acadesine 5'-monophosphate; ZMP; 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate; AICA Ribonucleotide Phosphate; AMPK Activator II
EINECS	Contact for details

Quality Control

Our Aicar (Phosphate) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards utilizing techniques such as HPLC, NMR, and mass spectrometry to verify product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.