Description

2-Thiophenecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci) is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in the unique reactivity of the acid chloride group combined with the electron-withdrawing and lipophilic properties of the trifluoromethyl substituent on the thiophene ring. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl-thiophene moiety enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating advanced polymers, liquid crystals, and organic electronic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Custom Synthesis & Contract Research: A vital reagent for custom synthesis houses and R&D laboratories engaged in exploratory chemistry and library synthesis for drug discovery.

Basic Information

Product Name	2-Thiophenecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci)
CAS No.	679807-08-0
Molecular Formula	C6H2ClF3OS
Molecular Weight	214.59 g/mol
Synonyms	5-(Trifluoromethyl)thiophene-2-carbonyl chloride; 5-(Trifluoromethyl)-2-thiophenecarbonyl chloride; 2-Thenoyl chloride, 5-(trifluoromethyl)-; 5-Trifluoromethylthiophene-2-carboxylic acid chloride; α-Trifluoromethyl-2-thiophenecarbonyl chloride; 5-Trifluoromethyl-2-thienoyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarbonyl Chloride, 5-(Trifluoromethyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis including HPLC/GC for purity and identity confirmation (IR, NMR). A detailed Certificate of Analysis (COA) specifying purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.