Description

Cyclopropanecarbonyl Chloride, 2-[(2R)-Tetrahydro-6-Oxo-2H-Pyran-2-Yl]-, (1S,2S)- (9Ci) is a high-value, stereochemically defined chiral building block and advanced pharmaceutical intermediate. Its precise molecular architecture, featuring fused cyclopropane and lactone moieties, makes it a critical synthon for constructing complex bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other specialized organic compounds. CAS No. 679429-93-7.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective reactions to introduce the cyclopropane-carbonyl chloride functional group with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in drug discovery pipelines.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential commercial APIs, where its defined stereochemistry ensures product consistency.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and other high-value products requiring complex, chiral molecular frameworks.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-[(2R)-Tetrahydro-6-Oxo-2H-Pyran-2-Yl]-, (1S,2S)- (9Ci)
CAS No.	679429-93-7
Molecular Formula	C9H11ClO3
Molecular Weight	202.63 g/mol
Synonyms	(1S,2S)-2-[(2R)-Tetrahydro-6-oxo-2H-pyran-2-yl]cyclopropanecarbonyl chloride; (1S,2S)-2-((2R)-Tetrahydro-2-oxo-2H-pyran-2-yl)cyclopropanecarbonyl chloride; (1S,2S)-2-[(2R)-6-Oxotetrahydro-2H-pyran-2-yl]cyclopropanecarbonyl chloride; (1S,2S)-2-((2R)-6-Oxotetrahydro-2H-pyran-2-yl)cyclopropanecarbonyl chloride; (1S,2S)-rel-2-[(2R)-Tetrahydro-6-oxo-2H-pyran-2-yl]cyclopropanecarbonyl chloride; Chiral Cyclopropane Lactone Acid Chloride; Advanced Chiral Synthon 679429-93-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, NMR, and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as chemical identity, assay purity, enantiomeric excess (ee), and impurity profiles. We support development and commercial projects with specifications tailored to your process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.