Description

Etamicastat Hcl Salt CAS NO 677773-32-9 is a high-purity, non-catecholamine, peripheral selective inhibitor of dopamine β-hydroxylase (DBH). This compound is of significant interest in pharmaceutical research and development, particularly for its potential role in modulating sympathetic nervous system activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutics for cardiovascular and neurological conditions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting dopamine β-hydroxylase.
• Cardiovascular Research: Used in preclinical studies to investigate new treatment pathways for hypertension and heart failure by reducing norepinephrine synthesis.
• Neuropharmacology Studies: Employed as a research tool to study the role of the sympathetic nervous system in various neurological disorders.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) assays to identify and characterize new DBH inhibitors.
• Process Chemistry: Acts as a critical intermediate in scale-up and optimization studies for Good Manufacturing Practice (GMP) production.

Basic Information

Product Name	Etamicastat Hcl Salt
CAS No.	677773-32-9
Molecular Formula	C14H21N3O3S • HCl
Molecular Weight	347.86 g/mol
Synonyms	Etamicastat Hydrochloride; (R)-5-(Aminomethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Hydrochloride; BIA 5-453; (R)-5-(Aminomethyl)-1-(6,8-difluoro-3,4-dihydro-2H-chromen-3-yl)-1,3-dihydro-2H-imidazole-2-thione Hydrochloride; DBH Inhibitor; Dopamine β-Hydroxylase Inhibitor
EINECS	Contact for details

Quality Control

Our Etamicastat Hcl Salt is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.