Description

5-Bromo-2'-Deoxy-4-Thiouridine is a modified nucleoside analog, a critical building block in advanced biochemical research and pharmaceutical development. Its unique structure, incorporating both bromine and a thio-substitution at the 4-position of the pyrimidine ring, makes it a valuable precursor for synthesizing oligonucleotides with specific properties. This compound is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, antisense oligonucleotide (ASO) synthesis, and nucleic acid chemistry. Its role is essential for probing biological mechanisms and developing next-generation therapeutic agents.

Application

• Antiviral and Anticancer Nucleoside Analog Synthesis: Serves as a key intermediate for developing novel therapeutic agents targeting viral replication and cancer cell proliferation.
• Antisense Oligonucleotide (ASO) and siRNA Production: Used to incorporate modified bases into oligonucleotides to enhance stability, specificity, and cellular uptake for gene silencing applications.
• Biochemical Research and Probe Development: Acts as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and function.
• Structural Studies of Nucleic Acids: Employed in X-ray crystallography and NMR spectroscopy to investigate the structure and dynamics of DNA and RNA.
• Diagnostic Reagent Manufacturing: Utilized in the creation of labeled probes and primers for molecular diagnostics and sequencing technologies.

Basic Information

Product Name	5-Bromo-2'-Deoxy-4-Thiouridine
CAS No.	676556-11-9
Molecular Formula	C9H11BrN2O4S
Molecular Weight	323.16 g/mol
Synonyms	4-Thio-5-bromo-2'-deoxyuridine; 5-Bromo-4-thio-2'-deoxyuridine; 5-Br-4-thio-dU; 2'-Deoxy-5-bromo-4-thiouridine; 4-Thiouridine, 5-bromo-2'-deoxy-; 5-Bromo-2'-deoxy-4-thio-Urd
EINECS	Contact for details

Quality Control

Our 5-Bromo-2'-Deoxy-4-Thiouridine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.