Description

(E)-3-(3-Bromo-4-Fluorophenyl)Acryloyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research institutions and industrial manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), liquid crystal materials, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates and active pharmaceutical ingredients (APIs), especially those targeting specific receptor sites.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the bromo-fluoro-phenyl moiety can impart specific biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of specialized liquid crystal compounds for display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as an intermediate in the synthesis of complex organic molecules used in OLED materials research.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to the presence of the bromine atom and the reactive acryloyl chloride group.
• Polymer Chemistry: Can be utilized as a monomer or co-monomer for creating specialty polymers with unique properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating complex molecular architectures.
• Fine Chemical Production: Integral to the multi-step synthesis of various high-value, low-volume specialty chemicals.

Basic Information

Product Name	(E)-3-(3-Bromo-4-Fluorophenyl)Acryloyl Chloride
CAS No.	676348-50-8
Molecular Formula	C9H5BrClFO
Molecular Weight	263.49 g/mol
Synonyms	(E)-3-(3-Bromo-4-fluorophenyl)prop-2-enoyl chloride; trans-3-(3-Bromo-4-fluorophenyl)acryloyl chloride; 3-(3-Bromo-4-fluorophenyl)-2-propenoyl chloride; (E)-3-(3-Bromo-4-fluorophenyl)acrylic acid chloride; 2-Propenoyl chloride, 3-(3-bromo-4-fluorophenyl)-, (E)-; 3-(3-Bromo-4-fluorophenyl)acryloyl chloride
EINECS	Contact for details

Quality Control

Our (E)-3-(3-Bromo-4-Fluorophenyl)Acryloyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. Certificates of Analysis (COA) detailing specific lot results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.