Description

(2-Chloro-4-Fluoro-Phenyl)-Acetyl Chloride is a high-purity, reactive aromatic acid chloride building block essential for advanced organic synthesis. Its value lies in its role as a key intermediate for introducing the (2-chloro-4-fluorophenyl)acetyl moiety, a privileged structural motif in medicinal chemistry. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents and antimicrobials.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated phenyl group enhances biological activity.
• Peptide Mimetics & Linker Chemistry: Serves as an acylating agent for coupling reactions, useful in creating peptide analogs and constructing molecular scaffolds.
• Material Science Research: Employed in the synthesis of specialized monomers and polymers for advanced materials with specific optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	(2-Chloro-4-Fluoro-Phenyl)-Acetyl Chloride
CAS No.	676348-45-1
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	2-Chloro-4-fluorophenylacetyl chloride; (2-Chloro-4-fluorophenyl)acetic acid chloride; 2-Chloro-4-fluoro-α-toluoyl chloride; (2-Chloro-4-fluorobenzene)acetyl chloride; α-Chloro-2-chloro-4-fluoroacetophenone; NSC 405124; (2-Chloro-4-fluoro-phenyl)-acetyl chloride
EINECS	Contact for details

Quality Control

Every batch of (2-Chloro-4-Fluoro-Phenyl)-Acetyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure compliance with exacting industry standards and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and alcohols; ensure containers are kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.