Description

(R)-1-[4-(tert-Butyldimethylsilyloxymethyl)Cyclohexyl]Ethan-1-Amine is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex, stereochemically defined molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling).
• Fine Chemical Building Block: Employed in academic and industrial R&D for constructing complex natural products and specialty molecules.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of chiral compounds.

Basic Information

Product Name	(R)-1-[4-(tert-Butyldimethylsilyloxymethyl)Cyclohexyl]Ethan-1-Amine
CAS No.	672314-51-1
Molecular Formula	C15H33NOSi
Molecular Weight	271.52 g/mol
Synonyms	(R)-1-[4-[(tert-Butyldimethylsilyl)oxymethyl]cyclohexyl]ethanamine; (1R)-1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]cyclohexyl]ethanamine; (R)-1-(4-((tert-Butyldimethylsilyloxy)methyl)cyclohexyl)ethanamine; (R)-TBDMS-protected Cyclohexyl Ethylamine; (R)-4-((tert-Butyldimethylsilyloxy)methyl)cyclohexanemethanamine; Chiral TBDMS-Cyclohexylamine Derivative
EINECS	Contact for details

Quality Control

Our production of (R)-1-[4-(tert-Butyldimethylsilyloxymethyl)Cyclohexyl]Ethan-1-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. All material is characterized by advanced analytical techniques including chiral HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.