Description

Crenolanib CAS NO 670220-88-9 is a potent and selective small-molecule inhibitor targeting specific tyrosine kinase receptors. This compound is of significant interest in advanced pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology and hematology therapeutic discovery.

Application

• Oncology Research: Investigated as a targeted therapeutic agent in preclinical and clinical studies for various cancers, including acute myeloid leukemia (AML) and gastrointestinal stromal tumors (GIST).
• Kinase Profiling & Selectivity Studies: Used as a critical tool compound to study signaling pathways involving platelet-derived growth factor receptors (PDGFR) and FMS-like tyrosine kinase 3 (FLT3).
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in drug manufacturing.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and in vitro assays to evaluate kinase inhibition and cellular efficacy.
• Mechanism of Action (MoA) Studies: Facilitates research into drug resistance mechanisms and combination therapy strategies in targeted cancer treatments.

Basic Information

Product Name	Crenolanib
CAS No.	670220-88-9
Molecular Formula	C26H29N5O3
Molecular Weight	459.54 g/mol
Synonyms	CP-868596; Benzamide, 4-[[(1-methyl-1H-indol-3-yl)methyl]amino]-N-[4-(4-methyl-1-piperazinyl)phenyl]-; Crenolanib besylate; 4-(((1-Methyl-1H-indol-3-yl)methyl)amino)-N-(4-(4-methylpiperazin-1-yl)phenyl)benzamide
EINECS	Contact for details

Quality Control

Our Crenolanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.