Description

(+)-(3R)-3-[(tert-Butyl(Dimethyl)Silyl)Oxy]Dihydrofuran-2(3H)-One CAS NO 669000-31-1 is a high-purity, chiral silyl-protected lactone derivative, serving as a critical chiral building block and synthetic intermediate. Its value lies in providing a protected hydroxyl group in a defined stereochemical configuration, enabling the stereoselective synthesis of complex molecules. This compound is essential for research and production in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral, anticancer, and other therapeutic agents.
• Asymmetric Synthesis: Used in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Natural Product Synthesis: Building block for the total synthesis of complex natural products containing lactone or furanone motifs.
• Process Chemistry: Employed in the scalable production of chiral compounds under GMP conditions for clinical and commercial APIs.
• Chemical Research: Valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and catalysis.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring specific chirality.

Basic Information

Product Name	(+)-(3R)-3-[(tert-Butyl(Dimethyl)Silyl)Oxy]Dihydrofuran-2(3H)-One
CAS No.	669000-31-1
Molecular Formula	C10H20O3Si
Molecular Weight	216.35 g/mol
Synonyms	(3R)-3-[(tert-Butyldimethylsilyl)oxy]dihydrofuran-2(3H)-one; (R)-3-((tert-Butyldimethylsilyl)oxy)dihydrofuran-2(3H)-one; (R)-3-(TBDMSO)-γ-butyrolactone; (R)-3-(tert-Butyldimethylsilyloxy)butyrolactone; (R)-3-Hydroxy-γ-butyrolactone TBDMS ether; TBDMS-protected (R)-3-hydroxybutyrolactone; (R)-3-TBDMSoxy-γ-butyrolactone; (3R)-3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2(3H)-furanone
EINECS	Contact for details

Quality Control

Our (+)-(3R)-3-[(tert-Butyl(Dimethyl)Silyl)Oxy]Dihydrofuran-2(3H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.