Description

7-Tfa-Ap-7-Deaza-Dg is a specialized nucleoside analog derivative, a key building block in oligonucleotide synthesis. This high-purity intermediate is critical for the development and production of modified nucleic acids used in advanced research and therapeutic applications. It is essential for pharmaceutical R&D, diagnostic assay development, and academic research focused on antisense technology, siRNA, and aptamer design.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate stable, nuclease-resistant modifications into therapeutic oligonucleotides to enhance their pharmacokinetic profile.
• Diagnostic Probe Development: Enables the creation of high-specificity probes for PCR, FISH, and microarray technologies with improved hybridization properties.
• Aptamer Engineering: Facilitates the generation of chemically modified aptamers (SELEX) with increased affinity and stability for target biomolecules.
• Basic Biochemical Research: Serves as a tool for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• XNA (Xeno Nucleic Acid) Synthesis: A component in the synthesis of artificial genetic polymers for synthetic biology applications.

Basic Information

Product Name	7-Tfa-Ap-7-Deaza-Dg
CAS No.	666847-77-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Deaza-7-trifluoroacetylaminopurine-2'-deoxyriboside; 7-TFA-7-deaza-2'-deoxyguanosine; 7-Trifluoroacetyl-7-deaza-2'-deoxyguanosine; 7-Deaza-7-(trifluoroacetamido)-2'-deoxyguanosine; 7-(Trifluoroacetamido)-7-deaza-2'-deoxyguanosine; 7-TFA-Amino-7-deaza-dG; N7-(Trifluoroacetyl)-7-deaza-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 7-Tfa-Ap-7-Deaza-Dg is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.