Description

5-Fluoro-4'-C-Methyluridine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. Its structural modifications make it a critical intermediate for the development of novel antiviral and anticancer therapeutics, particularly in the synthesis of modified oligonucleotides and prodrugs. This high-purity compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified building block for studying RNA structure, function, and enzyme interactions.
• Antisense Oligonucleotide Synthesis: Serves as a key monomer in the production of modified oligonucleotides for therapeutic and diagnostic applications.
• Prodrug Development: Employed in the design and synthesis of nucleoside prodrugs to enhance bioavailability and targeting.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Fluoro-4'-C-Methyluridine
CAS No.	660845-69-2
Molecular Formula	C11H15FN2O6
Molecular Weight	290.25 g/mol
Synonyms	4'-C-Methyl-5-fluorouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-4-methyl-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluoro-1-((2R,3R,4S,5R)-3,4-dihydroxy-4-methyl-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5-Fluoro-4'-methyluridine; 4'-Methyl-5-fluorouridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4'-C-Methyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with the rigorous standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.