Description

2-Fluoro-5-Methoxybenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of both fluorine and methoxy functional groups, enabling precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a fluorinated benzoyl moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, improving performance characteristics.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce specific functional groups into polymer chains, altering material properties.
• Peptide Coupling & Bioconjugation: Acts as an efficient acylating agent for amide bond formation in peptide synthesis and bioconjugate chemistry.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Fluoro-5-Methoxybenzoyl Chloride
CAS No.	659737-56-1
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	5-Methoxy-2-fluorobenzoyl chloride; 2-Fluoro-5-methoxybenzoic acid chloride; 2-Fluoro-5-methoxy-benzoyl chloride; 659737-56-1; 2-Fluoro-5-methoxybenzenecarbonyl chloride; 5-Methoxy-2-fluorobenzoic acid chloride; 2-Fluoro-5-methoxybenzoylchloride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methoxybenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reliable performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.