Description

α-D-Ribofuranoside, Methyl 5-Deoxy-5-[(1-Oxo-2-Propenyl)Amino]- (9Ci) is a specialized nucleoside derivative, a key building block in advanced organic synthesis and pharmaceutical research. Its modified ribose structure, featuring a deoxy and an acrylamido substitution, makes it a valuable precursor for the development of novel nucleotide analogs and bioactive molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors, particularly for applications in prodrug design and targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Prodrug Development: Used to create masked or targeted forms of active pharmaceutical ingredients (APIs) to improve bioavailability and reduce side effects.
• Bioconjugation & Labeling: The reactive acrylamido group enables site-specific conjugation with biomolecules for diagnostic and therapeutic applications.
• Chemical Biology Research: Serves as a tool compound for studying enzyme mechanisms and metabolic pathways involving nucleosides.
• Agrochemical Synthesis: A building block for developing new plant growth regulators or pesticides with novel modes of action.
• Oligonucleotide Synthesis: Potential use in the preparation of modified oligonucleotides for antisense or RNAi therapeutics.

Basic Information

Item	Details
Product Name	α-D-Ribofuranoside, Methyl 5-Deoxy-5-[(1-Oxo-2-Propenyl)Amino]- (9Ci)
CAS No.	656236-95-2
Molecular Formula	C10H15NO6
Molecular Weight	245.23 g/mol
Synonyms	Methyl 5-Deoxy-5-acrylamido-α-D-ribofuranoside; 5'-Deoxy-5'-acrylamidomethyl α-D-ribofuranoside; 5'-Acrylamido-5'-deoxymethyl α-D-ribofuranoside; 5-Acrylamido-5-deoxy-methyl-α-D-ribofuranoside; Acrylamido-modified methyl riboside; CAS 656236-95-2
EINECS	Contact for details

Quality Control

Our α-D-Ribofuranoside, Methyl 5-Deoxy-5-[(1-Oxo-2-Propenyl)Amino]- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.