Description

Brivanib is a potent and selective small-molecule inhibitor targeting vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) tyrosine kinases. This dual-action mechanism makes it a critical compound for research into anti-angiogenic cancer therapies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on oncology drug discovery and preclinical development.

Application

• Oncology Research: Primary application in the investigation of anti-angiogenic agents for various solid tumor models.
• Kinase Inhibitor Studies: Used as a reference standard in biochemical and cellular assays to study VEGFR and FGFR signaling pathways.
• Preclinical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the formulation of investigational new drugs (INDs).
• Mechanism of Action (MoA) Analysis: Employed to understand tumor microenvironment interactions and resistance mechanisms to targeted therapies.
• Biomedical Compound Libraries: A component of screening libraries for high-throughput discovery of novel cancer therapeutics.

Basic Information

Product Name	Brivanib
CAS No.	649735-46-6
Molecular Formula	C19H19FN4O3
Molecular Weight	370.38 g/mol
Synonyms	BMS-540215; Brivanib Alaninate; (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl 2-aminopropanoate; UNII-1E6V3I6S3U; BMS540215; Brivanib alaninate; 1-(4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)-2-propanol 2-aminopropanoate (ester)
EINECS	Contact for details

Quality Control

Our Brivanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.