Description

3'-o-(2-Methoxyethyl)-2-Thiouridine is a chemically modified nucleoside analog, specifically engineered for advanced research and development applications. This compound is valued for its role as a critical building block in the synthesis of oligonucleotides, where its unique thiolated and alkoxy-modified structure imparts specific properties to the final nucleic acid construct. It is primarily sought after by researchers and manufacturers in the fields of pharmaceutical development, antisense therapy, and diagnostic probe synthesis. The product is supplied with a commitment to high purity and batch-to-batch consistency to meet the stringent demands of life science applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense and siRNA Therapeutics: Used to incorporate stability-enhancing modifications into therapeutic oligonucleotides to improve nuclease resistance and pharmacokinetic profiles.
• Diagnostic Probe Development: Employed in the creation of high-affinity, labeled probes for molecular diagnostics and fluorescence in situ hybridization (FISH).
• Structural Biology Studies: Serves as a tool to investigate RNA structure, function, and protein-RNA interactions through site-specific modification.
• Aptamer Development: Utilized in SELEX processes to generate modified aptamers with enhanced binding characteristics and stability.
• Bioconjugation: The thiol group can serve as a handle for site-specific conjugation with labels, dyes, or other functional molecules.

Basic Information

Product Name	3'-o-(2-Methoxyethyl)-2-Thiouridine
CAS No.	647839-20-1
Molecular Formula	C12H18N2O7S
Molecular Weight	334.35 g/mol
Synonyms	2-Thio-3'-O-(2-methoxyethyl)uridine; 3'-O-Methoxyethyl-2-thiouridine; 2-Thiouridine, 3'-(2-methoxyethyl) ether; 3'-(2-Methoxyethoxy)-2-thiouridine; 2-Thio-3'-O-MOE-uridine; MOE-2-thiouridine; 3'-O-(2-Methoxyethyl)-2-thio-U; Modified Nucleoside S.4 (common research code)
EINECS	Contact for details

Quality Control

Every batch of 3'-o-(2-Methoxyethyl)-2-Thiouridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive life science applications. Our quality assurance protocol includes identity confirmation, purity assessment, and impurity profiling. Certificates of Analysis (COA) detailing specific batch results are available upon request, providing full transparency and traceability for your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.