Description

2'-C-Ethynyladenosine is a chemically modified nucleoside analog featuring an ethynyl group at the 2'-carbon position of the ribose sugar. This structural modification is of significant interest in medicinal chemistry and biochemistry for the development of antiviral and anticancer therapeutics. It serves as a critical building block and research tool for the synthesis of modified oligonucleotides and probes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Antiviral Drug Research: Key intermediate in the synthesis of nucleoside analogs targeting viral polymerases.
• Oncology Research: Investigated for incorporation into oligonucleotides designed to inhibit cancer cell proliferation.
• Biochemical Probes: Used to create labeled nucleotides for studying enzyme mechanisms and nucleic acid interactions.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for solid-phase synthesis of therapeutic RNA/DNA sequences.
• Enzyme Inhibition Studies: Acts as a substrate or inhibitor for enzymes like adenosine deaminase and kinases.
• Academic & Pharmaceutical R&D: Fundamental research compound for exploring novel nucleoside-based pharmacophores.

Basic Information

Product Name	2'-C-Ethynyladenosine
CAS No.	640725-76-4
Molecular Formula	C₁₂H₁₃N₅O₄
Molecular Weight	291.26 g/mol
Synonyms	2'-C-Ethynyladenosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-ethynyloxolan-2-yl]purin-6-amine; 2'-Ethynyladenosine; Adenosine, 2'-C-ethynyl-; 2'-Ethynyl-adenosine; 2'-C-EA; 2'-CEA; 2'-Ethynyl-A
EINECS	Contact for details

Quality Control

Our 2'-C-Ethynyladenosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.