Description

2-Pyridinecarbonyl Chloride, 4-Cyano- (9Ci) is a versatile and highly reactive heterocyclic building block used in advanced organic synthesis. Its core value lies in the combination of an acid chloride group and a cyano substituent on the pyridine ring, enabling efficient derivatization for creating complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of amide and ester derivatives in drug discovery and development, especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of functional polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 4-Cyano- (9Ci)
CAS No.	640296-18-0
Molecular Formula	C7H3ClN2O
Molecular Weight	166.56 g/mol
Synonyms	4-Cyanopyridine-2-carbonyl chloride; 4-Cyano-2-pyridinecarbonyl chloride; 4-Cyanopicolinoyl chloride; 2-Pyridinecarbonyl chloride, 4-cyano-; 4-Cyanopyridine-2-carboxylic acid chloride; Isonicotinonitrile-2-carbonyl chloride; Picolinoyl chloride, 4-cyano-
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridinecarbonyl Chloride, 4-Cyano- (9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from moisture, bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.