Description

Tozasertib is a potent and selective Aurora kinase inhibitor, a class of compounds critical for regulating cell division. This small molecule is a valuable research tool and pharmaceutical intermediate for developing targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on oncology and cell cycle biology.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-cancer drugs.
• Biochemical Assay Development: Used as a selective inhibitor to study the role and function of Aurora kinases (A, B, C) in various in vitro and cellular assays.
• Mechanism of Action Studies: Employed in preclinical research to investigate cell cycle regulation, mitosis, and apoptosis pathways in cancer cell lines.
• Oncology Drug Discovery: A critical building block for medicinal chemistry programs aimed at creating next-generation kinase inhibitors with improved efficacy and selectivity profiles.

Basic Information

Product Name	Tozasertib
CAS No.	639089-54-6
Molecular Formula	C₂₁H₂₀FN₅O₂
Molecular Weight	393.41 g/mol
Synonyms	MK-5108; VX-689; Aurora Kinase Inhibitor III; 4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]amino]benzonitrile; 4-({4-[4-Methylpiperazin-1-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)benzonitrile
EINECS	Contact for details

Quality Control

Our Tozasertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.