Description

Pazopanib Hydrochloride CAS NO 635702-64-6 is a potent and selective multi-targeted receptor tyrosine kinase inhibitor used as an active pharmaceutical ingredient (API). This compound is critical for the development and manufacturing of targeted cancer therapies, specifically for the treatment of advanced renal cell carcinoma and soft tissue sarcoma. It is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology drug development, formulation, and clinical trials.

Application

• Pharmaceutical API Manufacturing: Primary use as the active ingredient in the commercial production of anti-cancer medications.
• Oncology Research & Development: Serves as a key reference standard and investigational compound in preclinical and clinical studies for solid tumors.
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules, ensuring stability and bioavailability.
• Biochemical Research: Employed as a selective inhibitor to study angiogenesis and tumor cell signaling pathways involving VEGFR, PDGFR, and c-Kit.
• Quality Control & Analytical Testing: Functions as a high-purity reference standard in HPLC, LC-MS, and other analytical methods for drug testing and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and branded drug products.

Basic Information

Product Name	Pazopanib Hydrochloride
CAS No.	635702-64-6
Molecular Formula	C21H23N7O2 • HCl
Molecular Weight	473.92 g/mol (Free base: 437.46 g/mol)
Synonyms	Pazopanib HCl; GW786034 Hydrochloride; Votrient (Trade Name); 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Monohydrochloride; Pazopanib Monohydrochloride; Pazopanib Hydrochloride Salt; Pazopanib (Hydrochloride); UNII-3G6A5W8E5U
EINECS	Contact for details

Quality Control

Our Pazopanib Hydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, assay, purity, and specified impurities. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.