Description

5'-o-(2-Azido-2-Deoxy-β-D-Mannopyranosyl)-Uridine is a specialized nucleoside analog and a key synthetic intermediate in advanced biochemical research. This compound matters for its role in the development of novel oligonucleotide therapeutics and as a crucial building block for click chemistry applications in drug discovery. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense technology, carbohydrate chemistry, and the synthesis of modified RNA molecules.

Application

• Oligonucleotide Synthesis: A critical precursor for the solid-phase synthesis of modified RNA strands, enabling the study of structure-activity relationships.
• Click Chemistry Reagent: The azido functional group allows for efficient, bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling or linking biomolecules.
• Antisense & siRNA Research: Used to incorporate modifications into oligonucleotides aimed at enhancing stability, specificity, and delivery for therapeutic applications.
• Carbohydrate Chemistry Studies: Serves as a model compound for investigating glycosylation reactions and the properties of azido-sugars.
• Bioconjugation & Probe Development: Facilitates the creation of fluorescent or affinity probes for tracking nucleic acid interactions and metabolic pathways.
• Medicinal Chemistry: A valuable intermediate in the design and synthesis of nucleoside-based antiviral or anticancer prodrug candidates.

Basic Information

Product Name	5'-o-(2-Azido-2-Deoxy-β-D-Mannopyranosyl)-Uridine
CAS No.	635293-07-1
Molecular Formula	C15H19N5O10
Molecular Weight	429.34 g/mol
Synonyms	5'-O-(2-Azido-2-deoxy-β-D-mannopyranosyl)uridine; Uridine, 5'-O-(2-azido-2-deoxy-β-D-mannopyranosyl)-; 2'-Azido-2'-deoxy-5'-O-β-D-mannopyranosyluridine; 5'-O-(2-Azido-2-deoxy-β-D-mannosyl)uridine; Azido-Mannosyl-Uridine; AMU; N/A
EINECS	Contact for details

Quality Control

Our 5'-o-(2-Azido-2-Deoxy-β-D-Mannopyranosyl)-Uridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.