Description

5'-o-(2-Amino-2-Deoxy-D-Glucopyranosyl)-Thymidine is a sophisticated nucleoside analog where a glucosamine moiety is linked to the 5' position of thymidine. This compound matters as a key building block and intermediate in advanced pharmaceutical research, particularly in the development of novel antiviral and anticancer therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of modified oligonucleotides and prodrugs targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for creating specialized DNA/RNA sequences.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and glycosyltransferases.
• Prodrug Development: Utilized in designing targeted prodrugs that leverage sugar-mediated transport mechanisms for enhanced cellular uptake.
• Glycoconjugate Chemistry: Acts as a core structure for synthesizing more complex glycoconjugates with potential diagnostic or therapeutic applications.

Basic Information

Product Name	5'-o-(2-Amino-2-Deoxy-D-Glucopyranosyl)-Thymidine
CAS No.	631842-24-5
Molecular Formula	C₁₇H₂₅N₃O₁₀
Molecular Weight	431.40 g/mol
Synonyms	5'-O-(2-Amino-2-deoxy-β-D-glucopyranosyl)thymidine; Thymidine 5'-(2-amino-2-deoxy-β-D-glucopyranoside); 2'-Deoxy-5'-O-(2-amino-2-deoxy-β-D-glucopyranosyl)thymidine; 5'-Glucosaminylthymidine; N/A (Trade names vary by supplier)
EINECS	Contact for details

Quality Control

Our 5'-o-(2-Amino-2-Deoxy-D-Glucopyranosyl)-Thymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.