Description

5-Methyl-1H-Pyrazole-3-Carbonyl Chloride is a versatile and reactive acyl chloride derivative of a pyrazole heterocycle. This compound serves as a critical high-purity building block for the synthesis of more complex molecules, enabling the introduction of the 5-methylpyrazole-3-carboxamide moiety. It is primarily utilized by pharmaceutical R&D and agrochemical manufacturers engaged in developing new active ingredients, where its reactive carbonyl chloride group facilitates efficient amide bond formation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with pyrazole-based active ingredients.
• Ligand and Chelator Development: Used in organic and coordination chemistry to create specialized pyrazole-carboxamide ligands for catalysis or metal ion sensing.
• Material Science Research: Intermediate for synthesizing functional polymers or organic electronic materials containing heterocyclic units.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise molecular scaffold.

Basic Information

Product Name	5-Methyl-1H-Pyrazole-3-Carbonyl Chloride
CAS No.	625439-38-5
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	5-Methyl-1H-pyrazole-3-carbonyl chloride; 5-Methyl-1H-pyrazole-3-carboxylic acid chloride; 3-Carbonyl chloride-5-methyl-1H-pyrazole; 5-Methylpyrazole-3-carbonyl chloride; 1H-Pyrazole-3-carbonyl chloride, 5-methyl-; 5-Methyl-1H-pyrazole-3-carboxyl chloride
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing, including advanced chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request. We can support development projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.