Description

3-Isoxazolecarbonyl Azide, 5-(Fluoromethyl)- is a specialized heterocyclic building block featuring a reactive azide group and a fluoromethyl substituent. This compound is valued for its utility in advanced organic synthesis, particularly in click chemistry and the construction of complex molecular architectures. It is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and material science applications.
• Agrochemical Synthesis: Serves as a building block for creating new herbicides, fungicides, and insecticides with enhanced properties.
• Fluorine Chemistry: The fluoromethyl group makes it a valuable synthon for introducing fluorine atoms into target molecules to modulate their bioavailability, metabolic stability, and lipophilicity.
• Peptidomimetics & Protein Labeling: Used in the design and synthesis of peptide analogs and for site-specific labeling of proteins and antibodies.
• Material Science Research: Employed in the development of advanced polymers, coatings, and functionalized surfaces with specific chemical properties.

Basic Information

Product Name	3-Isoxazolecarbonyl Azide, 5-(Fluoromethyl)-
CAS No.	625120-08-3
Molecular Formula	C5H3FN4O2
Molecular Weight	170.10 g/mol
Synonyms	5-(Fluoromethyl)-1,2-oxazole-3-carbonyl azide; 5-(Fluoromethyl)isoxazole-3-carbonyl azide; 3-Azidocarbonyl-5-fluoromethylisoxazole; 5-Fluoromethyl-3-isoxazolecarbonyl azide; 1,2-Oxazole-3-carbonyl azide, 5-(fluoromethyl)-; 5-(Fluoromethyl)-3-isoxazolecarboxylic acid azide; 3-Carboxyazido-5-fluoromethylisoxazole (precursor acid form)
EINECS	Contact for details

Quality Control

Our 3-Isoxazolecarbonyl Azide, 5-(Fluoromethyl)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be opaque or stored in darkness. Handle and store away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.