Description

Tasidotin Hydrochloride is a synthetic derivative of dolastatin 15, functioning as a potent antimitotic agent that inhibits tubulin polymerization. This compound is of significant interest in oncology research for its potential as a cytotoxic payload in targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions engaged in the development of novel anticancer agents and antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced investigational oncology drugs.
• Antibody-Drug Conjugate (ADC) Payload: Used as the cytotoxic warhead component in the development of targeted ADC therapies.
• Biochemical Research: Employed as a reference standard and tool compound in studies of tubulin dynamics and cell cycle inhibition.
• Preclinical Development: Utilized in in vitro and in vivo studies to evaluate antitumor efficacy and mechanism of action.
• Process Chemistry: Acts as a critical intermediate for process development and scale-up activities in API manufacturing.

Basic Information

Product Name	Tasidotin Hydrochloride
CAS No.	623174-20-9
Molecular Formula	C34H55N5O7 • HCl
Molecular Weight	690.30 g/mol (free base: 653.83)
Synonyms	Synthadotin; ILX-651; (2R)-2-[(2S,5R,8S,11S)-5-Benzyl-11-[(3S)-3-(tert-butoxycarbonylamino)butyl]-8-(2-methylpropyl)-4,7,10-trioxo-3,6,9-triazadodec-1-yl]-N-[(1S)-1-[(dimethylamino)carbonyl]-2-methylpropyl]-N-methylpentanamide Hydrochloride; Tasidotin HCl; Dolastatin 15 Derivative
EINECS	Contact for details

Quality Control

Our Tasidotin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Total)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.